Preliminary Program

Final Program

07:00-08:45 Registration
08:45-09:00 Opening Remarks
09:00-09:45 Lecture by Jonathan Yewdell, DRiPs, SLiPs and Retirees : History of Immunopeptidomics from MHC Restriction to Millions of MS Defined Peptides
09:45-10:30 Lecture by Alex Jaeger, Experimental models to decode antigen presentation in vivo
10:30-11:00 Coffee Break
11:00-11:45 Lecture by Jacques Neefjes, Do we fully understand the process of antigen presentation by MHC molecules? Numbers, specificity and dynamics
12:00-13:30 Lunch and Sponsor’s talk
- Advances in sensitivity, accuracy, and quantitative performance of immunopeptidome measurements by Lilian Heil, Thermo Fisher Scientific
- Building High-Performance Off-the-Shelf Therapeutic Vaccines Based on Shared TSAs from the Cryptic Genome by Jon Moore, Epitopea

13:30-14:15 Lecture by Nicola Ternette, MHC antigen processing and purification
14:15-15:00 Lecture by Michal Bassani-Sternberg, Approaches for in-depth immunopeptidome analyses
15:00-15:45 Lecture by Stefan Tenzer, DDA vs DIA for Immunopeptidomics - may the better one win!
15:45-16:00 Flash Talks

09:00-9:45 Lecture by Alexey Nesvizhskii, Advanced immunopeptidomics workflows: PTMs and proteogenomics
09:45-10:30 Lecture by Karl Clauser, Challenges and Strategies to Maintain MS/MS Search Result Confidence when Identifying Neoantigens, Splice variants, Non-canonicals, & ERVs
10:30-11:00 Coffee Break
11:00-11:45 Lecture by Sisi Sarkizova, MHC (I and II) binding motifs and affinity prediction
12:00-13:30 Lunch and Sponsor’s talk
- Precision ImmunomicsTM: Translating immunopeptidomics to lifesaving cancer therapies by Jonathan Kwok, Infinitopes
- Targeting HLA/Peptides with Cell-Based Therapies: Target Discovery and De-risking Potential Off Targets by Robert Salzler and Kunal Kundu, Regeneron

Instrument Setup for Immunopeptidomics with David Gomez-Zepeda & Jenn Abelin

13:30-13:35 Opening remark by Jenn Abelin
13:35-14:20 Thermo Fisher instrument setup for immunopeptidomics with Jenn Abelin
14:20-15:05 Setting up timsTOF mass spectrometers for optimal immunopeptidomics profiling, dos and don’ts with David Gomez-Zepeda
15:05-15:15 Q&A

Immunopeptidome Data Analysis with Susan Klaeger

13:30-13:35 Opening remark by Susan Klaeger
13:35-14:05 Fragpipe tutorial with Alexey I. Nesvizhskii
14:05-14:35 Navigating data analysis using Peaks software with Susan Klaeger
14:35-15:05 Aiming an AI lens on the immunopeptidome - everything starts to look (a lot) bigger with Lennart Martens
15:05-15:15 Q&A

15:30-17:30 Flash Talks and Poster Session 2
From 17:30-18:00 Gathering for the Gala dinner. **Important: The bus will be leaving at 18:00**

09:00-9:45 Lecture by Cherryl Lichti, Challenges associated with the identification of post-translationally modified neoantigens
09:45-10:30 Lecture by Alessandro Sette, Epitope and antigen immunoprofiling to understand symptomatic versus asymptomatic infections
10:30 - 11:00 Coffee Break
11:00 -11:45 Lecture by Johanna Olweus, Opportunities for T-cell receptors in cancer immunotherapy
12:00-13:30 Lunch and Sponsor’s talk
- AI-driven massspectrometry-based immunopeptidomics pipeline for neoantigen identificationand validation by Paul Shan, BSI
- Benefiting Cancer Patients with the Potential of Immunopeptidomics by Lena Freudenmann, Immatics

13:30-14:15 Lecture by Shira Weingarten-Gabbay, Shedding light on the dark matter of viral proteomes to advance our understanding of antiviral immunity
14:15-15:00 Lecture by Pere Santamaria, Peptide-MHC-based nanomedicines for the treatment of autoimmunity: engineering, diseases, mechanisms
15:00-15:45 Lecture by Andrew K. Sewell, T-cell cross-reactivity: perils [autoimmunity] and potential benefits [cancer]
15:45-16:30 Poster awards and closing statement