Tuesday, 13.08.2024 – 13:00 to 15:00

• Registration

Wednesday, 14.08.2024 – 09:00 to 11:45

Immunopeptidomics – From genesis to isolation

• 07:00-08:45 Registration

• 08:45-09:00 Opening Remarks

• 09:00-09:45 Lecture by Jonathan Yewdell, Antigen discovery – Historical perspectives, genesis and classes of antigens

• 09:45-10:30 Lecture by Alex Jaeger, Experimental models for in vivo analysis of lineage-restricted immunopeptidome

• 10:30-11:00 Coffee Break

• 11:00-11:45 Lecture by Jacques Neefjes, New paradigms on alternative Sources of MHC Class I Peptides

• 12:00-13:30 Lunch and Sponsor’s talk

Wednesday, 14.08.2024 – 13:30 to 16:00

Antigen Discovery

• 13:30-14:15 Lecture by Nicola Ternette, MHC antigen processing and purification

• 14:15-15:00 Lecture by Michal Bassani-Sternberg, Approaches for in-depth immunopeptidome analyses

• 15:00-15:45 Lecture by Stefan Tenzer, DIA and multiplex immunopeptidomic analyses

• 15:45-16:00 Flash Talks

• From 16:00 Poster Session 1 with Drinks Reception and Sponsor networking event

Thursday, 15.08.2024 – 09:00 to 11:45

Data Analysis

• 09:00-9:45 Lecture by Alexey Nesvizhskii Proteogenomics and building personalized databases

• 09:45-10:30 Lecture by Karl Clauser, Search engines – Lessons and challenges

• 10:30-11:00 Coffee Break

• 11:00-11:45 Lecture by Sisi Sarkizova, MHC (I and II) binding motifs and affinity prediction

• 12:00-13:30 Lunch and Sponsor’s talk

Thursday, 15.08.2024 – 13:30 to 15:15

Practical immunopeptidomics - Breakout Session 1

Instrument Setup for Immunopeptidomics with David Gomez-Zepeda & Jenn Abelin

• 13:30-13:35 Opening remark by Jenn Abelin

• 13:35-14:20 Setup of Thermo Fisher MS with Jenn Abelin

• 14:20-15:05 Setup of Bruker MS with David Gomez-Zepeda

• 15:05-15:15 Q&A

Practical immunopeptidomics - Breakout Session 2

Immunopeptidome Data Analysis with Susan Klaeger

• 13:30-13:35 Opening remark by Susan Klaeger

• 13:35-14:05 MS Fragger with Alexey I. Nesvizhskii

• 14:05-14:35 Peaks (Speaker TBD)

• 14:35-15:05 Considerations for spectral prediction features and DIA analysis with Lennart Martens

• 15:05-15:15 Q&A

• 15:30-17:30 Flash Talks and Poster Session 2

• From 17:30-18:00 Gathering for the Gala dinner. **Important: The bus will be leaving at 18:00**

Friday, 16.08.2024 – 09:00 to 11:45

Translational immunopeptidomics

• 09:00-9:45 Lecture by Cherryl Lichti, Autoimmunity: Identifying the targets of auto-reactive T cells

• 09:45-10:30 Lecture by Alessandro Sette, Immunogenicity testing: selecting the best antigens

• 10:30 - 11:00 Coffee Break

• 11:00 -11:45 Lecture by Johanna Olweus, Selecting safe and effective TCRs for cancerimmunotherapy

• 12:00-13:30 Lunch

Friday, 16.08.2024 – 13:30 to 16:00

Immunosurveillance and immunotherapy

• 13:30-14:15 Lecture by Shira Weingarten-Gabbay, The immunopeptidome of virus-infected cells

• 14:15-15:00 Lecture by Pere Santamaria, Induction of antigen-specific tolerance

• 15:00-15:45 Lecture by Andrew K. Sewell, T-cell cross-reactivity: perils [autoimmunity] and potential benefits [cancer]

• 15:45-16:30 Poster awards and closing statement